Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:
15703176, PubMed:
16835243, PubMed:
17337452, PubMed:
17217311, PubMed:
23614568, PubMed:
28691797, PubMed:
29787766, PubMed:
31990367, PubMed:
22329685). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (PubMed:
15703176, PubMed:
16835243). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met- AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (PubMed:
15703176, PubMed:
22329685, PubMed:
17337452). Hydrolyzes 3-indolepropionic acyl- adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:
17337452, PubMed:
23614568, PubMed:
29787766, PubMed:
17217311, PubMed:
28691797, PubMed:
31990367). Can also convert adenosine 5'-O- phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (PubMed:
30772266). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (PubMed:
16014379, PubMed:
22647378). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis (PubMed:
16835243). Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:
19112177). Also exhibits SUMO- specific isopeptidase activity, deconjugating SUMO1 from RGS17 (PubMed:
31088288). Deconjugates SUMO1 from RANGAP1 (By similarity).
