产品名称
BLNK (3S3) Rabbit Monoclonal Antibody
别名
AGM4; BASH; Bca; BLNK; Ly57; Lyw57; SLP65;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q8WV28
免疫原
A synthetic peptide of human BLNK
稀释度
WB: 1:1000 IHC: 1:20 IP: 1:20
注意事项
BLNK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon
细胞定位
Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction
功能
Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR- induced B-cell apoptosis.
