RM6846

LAT (17B18) Rabbit Monoclonal Antibody

lat; LAT1; pp36;

Affinity-chromatography

常规抗体

LAT

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

27040

O43561

A synthetic peptide of human LAT

WB: 1:1000 IHC: 1:20 FC: 1:20 IP: 1:20

36kDa

28kDa

Rabbit IgG

LAT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).

Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts

Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

现货