RM6838

HMG4 (17I13) Rabbit Monoclonal Antibody

HMG 4; HMG2A; Hmgb3;

Affinity-chromatography

常规抗体

HMGB3

HMG2A, HMG4

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

3149

O15347

A synthetic peptide of human HMG4

WB: 1:2000-1:10000

23kDa

23kDa

Rabbit IgG

HMG4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed predominantly in placenta.

Nucleus {ECO:0000250|UniProtKB:P40618, ECO:0000255|PROSITE-ProRule:PRU00267}. Chromosome Cytoplasm {ECO:0000250|UniProtKB:O54879}

Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity).

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