产品名称
Ube2L3 / UBCH7 (11O13) Rabbit Monoclonal Antibody
别名
UBCE7; UbcH7; UbcM4; Ube2l3;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P68036
免疫原
A synthetic peptide of human Ube2L3/UBCH7
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 IP: 1:20
注意事项
Ube2L3 / UBCH7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitous, with highest expression in testis.
功能
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
