RM6840

AMSH (14B1) Rabbit Monoclonal Antibody

AMSH; MICC/IFAP; STAM binding protein; Stambp;

Affinity-chromatography

常规抗体

STAMBP

AMSH

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

10617

O95630

A synthetic peptide of human AMSH

WB 1:1000

48kDa

48kDa

Rabbit IgG

AMSH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Ubiquitously expressed.

Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome

Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM- CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

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