产品名称
ZHX2 (15T8) Rabbit Monoclonal Antibody
别名
AFP regulator 1; AFR1; Alpha fetoprotein regulator 1; RAF; Regulator of AFP; Transcription factor ZHX2;ZHX2; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9Y6X8
免疫原
Recombinant protein of human ZHX2
稀释度
WB: 1:1000 ICC/IF: 1:50 FC: 1:20
注意事项
ZHX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed. Expressed in podocytes.
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12741956, ECO:0000269|PubMed:17056598} Note=Colocalizes with EFNB1 intracellular domain in the nucleus {ECO:0000250|UniProtKB:Q8C0C0}
功能
Acts as a transcriptional repressor (PubMed:
12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:
12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
