产品名称
ZHX2 (15T8) Rabbit Monoclonal Antibody
别名
AFP regulator 1; AFR1; Alpha fetoprotein regulator 1; RAF; Regulator of AFP; Transcription factor ZHX2;ZHX2; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9Y6X8
免疫原
Recombinant protein of human ZHX2
注意事项
ZHX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed. Expressed in podocytes.
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12741956, ECO:0000269|PubMed:17056598} Note=Colocalizes with EFNB1 intracellular domain in the nucleus {ECO:0000250|UniProtKB:Q8C0C0}
功能
Acts as a transcriptional repressor (PubMed:
12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:
12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
