产品名称
Phospho-Rad17 (S656) (16A8) Rabbit Monoclonal Antibody
别名
CCYC; hRad17; R24L; RAD17; Rad24;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O75943
免疫原
A synthetic phosphopeptide corresponding to residues surrounding Ser656 of human Rad17
稀释度
WB: 1:1000-1:5000 IHC: 1:501:50
注意事项
Phospho-Rad17 (S656) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level) Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli Weakly expressed in seminomas (testicular tumors)
细胞定位
Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage
功能
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
