产品名称
Semaphorin 4D / CD100 (13A9) Rabbit Monoclonal Antibody
别名
BB18; CD100; COLL4; Collapsin 4; GR3; MSEMA; Sema4d; Semacl2; SemaH; SEMAJ; Semaphorin 4D; Semaphorin H; Semaphorin J; Semcl2;
纯度
Affinity-chromatography
蛋白名称
C9orf164, CD100, SEMAJ
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q92854
免疫原
A synthetic peptide of human Semaphorin 4D
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:100 ICC/IF: 1:20-1:100
注意事项
Semaphorin 4D / CD100 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver
细胞定位
Cell membrane; Single-pass type I membrane protein
功能
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:
20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:
19788569). Promotes the migration of cerebellar granule cells (PubMed:
16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:
8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:
16055703).
