产品名称
HIF Prolyl Hydroxylases (11V1) Rabbit Monoclonal Antibody
别名
EGLN4 ; HIFPH4; Hypoxia inducible factor prolyl 4 hydroxylase; P4H with transmembrane domain; P4htm; PH4; PHD4; Proline 4 hydroxylase; Prolyl hydroxlase domain containing 4;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9NXG6
免疫原
A synthetic peptide of human HIF Prolyl Hydroxylases
稀释度
WB: 1:1000 IHC: 1:50 FC: 1:50 IP: 1:20
注意事项
HIF Prolyl Hydroxylases Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts.
细胞定位
Endoplasmic reticulum membrane; Single-pass type II membrane protein
功能
Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
