产品名称
CCDC98 (18V2) Rabbit Monoclonal Antibody
别名
ABRA1; ABRAXAS; FAM175A;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q6UWZ7
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:50
注意事项
CCDC98 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
功能
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
