产品名称
NUD12 Rabbit Polyclonal Antibody
蛋白名称
Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9BQG2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BQG2/entry
Mouse Swissprot No.
Q9DCN1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DCN1
免疫原
Synthesized peptide derived from human protein . at AA range: 80-160
特异性
NUD12 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008],
细胞定位
Cytoplasm . Peroxisome . Cytoplasmic granule . Localizes to cytoplasmic granules in the presence of BLMH. .
信号通路
Nicotinate and nicotinamide metabolism;
功能
catalytic activity:NAD(+) + H(2)O = AMP + NMN.,cofactor:Magnesium or manganese.,function:Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.,similarity:Belongs to the Nudix hydrolase family. NudC subfamily.,similarity:Contains 3 ANK repeats.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
