产品名称
TRPV5 (9W9) Rabbit Monoclonal Antibody
别名
CAT2; ECaC; ECaC1; OTRPC3; TrpV5;
纯度
Affinity-chromatography
蛋白名称
ECAC1 {ECO:0000303|PubMed:10945469}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9NQA5
免疫原
A synthetic peptide of human TRPV5
稀释度
WB: 1:2000-1:10000 IHC: 1:50 FC: 1:20-1:100 IP: 1:20
注意事项
TRPV5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.
细胞定位
Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity) The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (PubMed:18768590) {ECO:0000250|UniProtKB:P69744, ECO:0000269|PubMed:18768590}
功能
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:
11549322, PubMed:
18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:
11549322, PubMed:
18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
