RM6745

CHM (1R18) Rabbit Monoclonal Antibody

CHM; Choroideraemia protein; GGTA; REP1; TCD;

Affinity-chromatography

常规抗体

CHM

REP1, TCD

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

1121

P24386

WB 1:500~1:2000 ICC/IF 1:50~1:200

73kDa

Rabbit IgG

CHM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm, cytosol.

Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.

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