产品名称
ITPA (8W11) Rabbit Monoclonal Antibody
别名
Inosine triphosphatase; Itpa; ITPase; My049; NTPase;
纯度
Affinity-chromatography
基因名称
ITPA {ECO:0000255|HAMAP-Rule:MF_03148}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9BY32
免疫原
A synthetic peptide of human Inosine triphosphate pyrophosphatase
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:50
注意事项
ITPA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland
细胞定位
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}
功能
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
