产品名称
IL11RA (8A4) Rabbit Monoclonal Antibody
别名
CRSDA; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL11RA; Interleukin 11 receptor alpha; Interleukin 11 receptor alpha chain;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q14626
免疫原
A synthetic peptide of human IL11RA
稀释度
WB: 1:1000 IHC: 1:100 ICC/IF: 1:50 FC: 1:20-1:100
注意事项
IL11RA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2 (PubMed:7670098). Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.
细胞定位
[Interleukin-11 receptor subunit alpha]: Membrane; Single-pass type I membrane protein [Isoform HCR2]: Secreted
功能
Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
