产品名称
NOP10 (7I6) Rabbit Monoclonal Antibody
别名
DKCB1; NOLA3; NOP10; NOP10P;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9NPE3
免疫原
A synthetic peptide of human NOP10
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:50
注意事项
NOP10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies)
功能
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
