RM6727

PPP6C (9I3) Rabbit Monoclonal Antibody

PP6; PP6C; PPP6; Ppp6c;

Affinity-chromatography

常规抗体

PPP6C

PPP6

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

5537

O00743

WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50

35kDa

Rabbit IgG

PPP6C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.

Mitochondrion. Cytoplasm

Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG- I/DDX58-mediated signaling activation (PubMed:29053956).

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