RM6713

Adenylate kinase 4 (14Y15) Rabbit Monoclonal Antibody

AK3; AK3L1; AK3L2; AK4;

Affinity-chromatography

常规抗体

AK4 {ECO:0000255|HAMAP-Rule:MF_03170}

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

205

P27144

A synthetic peptide of human AK3L1

WB: 1:1000 IHC: 1:20 ICC/IF: 1:50 IP: 1:20

25kDa

25kDa

Rabbit IgG

Adenylate kinase 4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain

Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03170, ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:26980435}

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (PubMed:19073142, PubMed:19766732, PubMed:23416111). Also displays broad nucleoside diphosphate kinase activity (PubMed:19073142, PubMed:19766732, PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435).

现货