RM6698

ARPC2 (1R14) Rabbit Monoclonal Antibody

ARC34; Arpc2; p34Arc; PNAS139; PRO2446;

Affinity-chromatography

常规抗体

ARPC2

ARC34

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

10109

O15144

A synthetic peptide of human ARPC2

WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 IP: 1:20

34kDa

34kDa

Rabbit IgG

ARPC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm, cytoskeleton. Cell projection. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q9CVB6}. Nucleus

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

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