RM6686

RGMA (19C12) Rabbit Monoclonal Antibody

Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA;

Affinity-chromatography

常规抗体

RGMA

RGM

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

56963

Q96B86

WB 1:500~1:2000 ICC/IF 1:50~1:200

49kDa

Rabbit IgG

RGMA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cell membrane; Lipid-anchor, GPI- anchor

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1- AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

现货