RM6670

Erlin-2 (17J6) Rabbit Monoclonal Antibody

ERLIN2; NET32; SPFH2;

Affinity-chromatography

常规抗体

ERLIN2

C8orf2, SPFH2

WB

Human,Mouse

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

11160

O94905

A synthetic peptide of human Erlin-2

WB: 1:1000 IHC: 1:100 ICC/IF: 1:100

43kDa

38kDa

Rabbit IgG

Erlin-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Ubiquitous..

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618).

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