产品名称
MBD3 (19N9) Rabbit Monoclonal Antibody
别名
Mbd3; Methyl CpG binding domain protein 3;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
O95983
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
MBD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes
功能
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:
12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:
24307175). Recruits histone deacetylases and DNA methyltransferases.
