产品名称
P2RX1 Rabbit Polyclonal Antibody
蛋白名称
P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P51575
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P51575/entry
Mouse Swissprot No.
P51576
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51576
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P47824
免疫原
Synthesized peptide derived from human protein . at AA range: 150-230
特异性
P2RX1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013],
组织表达
Blood,Lung,Placenta,Platelet,Urinary bladder,Urinary bladder smooth muscle,
细胞定位
Membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;
功能
disease:Defects in P2RX1 are a cause of bleeding disorder [MIM:600845].,function:Ligand gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.,online information:P2RX1 entry,online information:P2X receptor entry,similarity:Belongs to the P2X receptor family.,subunit:Homo- or heteropolymers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
