RM6601

DMAP1 (19X17) Rabbit Monoclonal Antibody

DNA methyltransferase 1 associated protein 1; DNMAP1; DNMTAP1; EAF2; SWC4;

Affinity-chromatography

常规抗体

DMAP1

KIAA1425

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

55929

Q9NPF5

WB 1:500~1:2000 ICC/IF 1:50~1:200

53kDa

Rabbit IgG

DMAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1

Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.

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