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ERCC8 (3A18) Rabbit Monoclonal Antibody

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产品基本信息

产品货号
RM6589
产品名称
ERCC8 (3A18) Rabbit Monoclonal Antibody
别名
CKN1; CSA; ERCC8;
纯度
Affinity-chromatography
类别
常规抗体
基因名称
ERCC8
蛋白名称
CKN1, CSA
推荐应用
WB
反应种属
Human
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Gene ID
1161
Human Swissprot No.
Q13216
免疫原
A synthetic peptide of human ERCC8
稀释度
WB: 1:1000 IP: 1:20
参考分子量
44kDa
预测分子量
44kDa
同种型
Rabbit IgG
注意事项
ERCC8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus. Nucleus matrix. Note=UV-induced translocation to the nuclear matrix is dependent on ERCC6.
功能
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Plays a role in DNA single-strand and double- strand breaks (DSSBs) repair; involved in repair of DSSBs by non- homologous end joining (NHEJ) (PubMed:29545921).
期货
现货

Western blot analysis of ERCC8 expression in Molt4 cell lysate.

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