产品名称
ATP4B (10P15) Rabbit Monoclonal Antibody
别名
ATP4B; Gastric H(+)/K(+) ATPase subunit beta; Potassium-transporting ATPase subunit beta; ATPase H+/K+ exchanging beta polypeptide
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P51164
注意事项
ATP4B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Apical cell membrane {ECO:0000250|UniProtKB:P20648}; Single-pass type II membrane protein. Cell membrane {ECO:0000250|UniProtKB:P18597}; Single- pass type II membrane protein. Note=Localized in the apical canalicular membrane of parietal cells {ECO:0000250|UniProtKB:P20648}
功能
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity).
