产品名称
NR2C2 Rabbit Polyclonal Antibody
蛋白名称
Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P49116
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49116/entry
Mouse Swissprot No.
P49117
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P49117
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P55094
免疫原
Synthesized peptide derived from human protein . at AA range: 410-490
特异性
NR2C2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014],
功能
developmental stage:Transiently repressed during the meiotic phase of spermatogenesis.,function:Orphan nuclear receptor. May regulate gene expression during the late phase of spermatogenesis.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with NR2C2AP/TRA16 which represses the activity of NR2C2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
