产品名称
SLC27A4 / FATP4 (15B5) Rabbit Monoclonal Antibody
别名
ACSVL4; FATP4; Fatty acid transport protein 4; IPS; S27A4; Solute carrier family 27 member4;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q6P1M0
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:100
注意事项
SLC27A4 / FATP4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue (PubMed:24269233, PubMed:9878842). Expressed in brain gray matter (PubMed:21395585).
细胞定位
Endoplasmic reticulum membrane; Multi-pass membrane protein
功能
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane (PubMed:
12556534, PubMed:
21395585). Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs) (PubMed:
24269233). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:
21395585). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).
