RM6561

WDR4 (3C12) Rabbit Monoclonal Antibody

TRM82; WD repeat protein 4; wdr4;

Affinity-chromatography

常规抗体

WDR4 {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000312|HGNC:HGNC:12756}

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

10785

P57081

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50

45kDa

Rabbit IgG

WDR4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus. Chromosome Note=Localizes at the site of nascent DNA synthesis

Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (PubMed:12403464). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069).

现货