产品名称
DCOR Rabbit Polyclonal Antibody
蛋白名称
Ornithine decarboxylase (ODC) (EC 4.1.1.17)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P11926
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P11926/entry
Mouse Swissprot No.
P00860
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P00860
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P09057
免疫原
Synthesized peptide derived from human protein . at AA range: 250-330
特异性
DCOR Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
ornithine decarboxylase 1(ODC1) Homo sapiens This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013],
组织表达
Esophagus,Lymph,Testis,
细胞定位
cytoplasm,cytosol,perinuclear region of cytoplasm,
信号通路
Arginine and proline metabolism;Glutathione metabolism;
功能
catalytic activity:L-ornithine = putrescine + CO(2).,cofactor:Pyridoxal phosphate.,enzyme regulation:Inhibited by S-nitrosylation.,online information:Ornithine decarboxylase entry,pathway:Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.,PTM:S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.,similarity:Belongs to the Orn/Lys/Arg decarboxylase class-II family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
