产品名称
HMGCS2 (13A8) Rabbit Monoclonal Antibody
别名
HMG CoA synthase; HMGCS2;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P54868
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
HMGCS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161). Not detected in brain (PubMed:21952825).
细胞定位
Mitochondrion {ECO:0000250|UniProtKB:P22791}.
功能
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
