产品名称
DOK1 (11F11) Rabbit Monoclonal Antibody
别名
DOK1; p62(dok); P62DOK; pp62;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q99704
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200
注意事项
DOK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells Expressed in breast cancer.
细胞定位
[Isoform 1]: Cytoplasm. Nucleus.
功能
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
