RM6496

PLAP (12K11) Rabbit Monoclonal Antibody

Glycerophosphatase; PLA2P; Plaa; PLAP;

Affinity-chromatography

常规抗体

PLAA

PLAP

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

9373

Q9Y263

A synthetic peptide of human Anti-Phospholipase A2 activator protein (PLAP)

WB: 1:1000 IHC: 1:20-1:50 ICC/IF: 1:20

87kDa

87kDa

Rabbit IgG

PLAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus. Cytoplasm. Cell junction, synapse {ECO:0000250|UniProtKB:P27612}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains

Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).

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