RM6471

Arp2 (16Y19) Rabbit Monoclonal Antibody

ACTR2; ARP2; ARP2/3 COMPLEX;

Affinity-chromatography

常规抗体

ACTR2

ARP2

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

10097

P61160

A synthetic peptide of human Arp2

WB: 1:1000 IHC: 1:50 ICC/IF: 1:50

45kDa

45kDa

Rabbit IgG

Arp2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm, cytoskeleton. Cell projection. Nucleus

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

现货