RM6457

DLDH (7X13) Rabbit Monoclonal Antibody

Diaphorase; Dihydrolipoamide dehydrogenase; DLDD; DLDH; GCSL; LAD; lipoamide dehydrogenase; Lipoamide reductase; Lipoyl dehydrogenase; PHE3;

Affinity-chromatography

常规抗体

DLD

GCSL, LAD, PHE3

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

1738

P09622

A synthetic peptide of human Lipoamide Dehydrogenase

WB: 1:2000-1:10000 IHC: 1:20-1:100 ICC/IF: 1:20-1:50

54kDa

54kDa

Rabbit IgG

DLDH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Mitochondrion matrix. Nucleus. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q811C4}. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2- oxoglutarate dehydrogenase complex is required for histone succinylation.

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2- oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).

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