RM6453

TEAD1 (1E8) Rabbit Monoclonal Antibody

NTEF1; REF1; TCF13; TEA domain family member 1; TEAD1; TEF 1; Transcription factor 13;

Affinity-chromatography

常规抗体

TEAD1

TCF13, TEF1

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

7003

P28347

WB 1:500~1:2000 ICC/IF 1:50~1:200

48kDa

Rabbit IgG

TEAD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart

Nucleus.

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

现货