RM6451

SENP2 (2D11) Rabbit Monoclonal Antibody

Axam2; Senp2; Sentrin specific protease 2; SMT3 specific isopeptidase 2; Smt3ip2;

Affinity-chromatography

常规抗体

SENP2

KIAA1331

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

59343

Q9HC62

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

68kDa

Rabbit IgG

SENP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm Note=Shuttles between cytoplasm and nucleus

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).

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