产品名称
CSK (1J7) Rabbit Monoclonal Antibody
别名
C SRC; Csk A; CSK; P60 Src;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P41240
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
CSK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in lung and macrophages.
细胞定位
Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts
功能
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
