RM6424

ATP7b (3D19) Rabbit Monoclonal Antibody

ATP7B; PWD; WC1; WD; WND; WND/140 kDa;

Affinity-chromatography

常规抗体

ATP7B

PWD, WC1, WND

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

540

P35670

WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50

157kDa

Rabbit IgG

ATP7b Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome Note=Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). [Isoform 2]: Cytoplasm

Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.

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