产品名称
HRH3 (6P12) Rabbit Monoclonal Antibody
别名
GPCR97; H3R; HH3R; Histamine H3 receptor; HRH3;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9Y5N1
免疫原
A synthetic peptide of human HRH3/Histamine 3 Receptor
稀释度
WB: 1:1000 ICC/IF: 1:50 FC: 1:20-1:100
注意事项
HRH3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
