RM6395

Thromboxane synthase (9H19) Rabbit Monoclonal Antibody

TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14;

Affinity-chromatography

常规抗体

TBXAS1

CYP5, CYP5A1 {ECO:0000303|PubMed:1146554

WB

Human,Mouse

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

6916

P24557

WB 1:500~1:2000

61kDa

Rabbit IgG

Thromboxane synthase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.

Endoplasmic reticulum membrane; Multi-pass membrane protein

Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:8436233, PubMed:11297515, PubMed:9873013, PubMed:11097184, PubMed:24009185, PubMed:22735388). Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12- HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:9873013, PubMed:22735388). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy- (5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323).

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