RM6391

Tbx3 (13T6) Rabbit Monoclonal Antibody

T box 3; T-box protein 3; Tbx3; TBX3 ISO; UMS; XHL;

Affinity-chromatography

常规抗体

TBX3

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

6926

O15119

WB 1:500~1:2000 IP 1:50 FC 1:100

79kDa

Rabbit IgG

Tbx3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed.

Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.

Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'- TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537).

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