产品名称
Pannexin 1 (18U7) Rabbit Monoclonal Antibody
别名
innexin; MRS1; Pannexin 1; Panx1; PX1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q96RD7
稀释度
WB 1:500~1:2000 IP 1:50
注意事项
Pannexin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed (PubMed:30918116). Highest expression is observed in oocytes and brain (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116)
细胞定位
Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351} Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000255|PROSITE- ProRule:PRU00351}
功能
Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:
16908669, PubMed:
20829356, PubMed:
30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:
16908669). Plays a critical role in oogenesis (PubMed:
30918116).
