产品名称
NR0B2 Rabbit Polyclonal Antibody
蛋白名称
Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q15466
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15466/entry
Mouse Swissprot No.
Q62227
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62227
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97947
免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
NR0B2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008],
组织表达
Liver. Low levels of expression were detected in heart and pancreas.
细胞定位
Nucleus . Cytoplasm . Colocalizes with NEUROD1 in the nucleus.
功能
disease:Defects in NR0B2 may be associated with early-onset obesity [MIM:601665].,function:Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts.,similarity:Belongs to the nuclear hormone receptor family. NR0 subfamily.,subunit:Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A.,tissue specificity:Liver. Low levels of expression were detected in heart and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
