Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:
1944575, PubMed:
17435751, PubMed:
20668449, PubMed:
22215983, PubMed:
11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:
12194828, PubMed:
17435751, PubMed:
22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:
22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:
3678831). Binds both to the nucleosomes and double- stranded DNA (PubMed:
17435751, PubMed:
18762580).
