产品名称
EDD (16Z19) Rabbit Monoclonal Antibody
别名
DD5; EDD; EDD1; hHYD; HYD; Rat100; Ubiquitin protein ligase; UBR5;
纯度
Affinity-chromatography
蛋白名称
EDD, EDD1, HYD, KIAA0896
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
O95071
注意事项
EDD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney
功能
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
