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CARD11 (6T8) Rabbit Monoclonal Antibody

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产品基本信息

产品货号
RM6367
产品名称
CARD11 (6T8) Rabbit Monoclonal Antibody
别名
CARD11; CARMA1; Carma 1; BIMP3;
纯度
Affinity-chromatography
类别
常规抗体
基因名称
CARD11 {ECO:0000303|PubMed:11278692, ECO:0000312|HGNC:HGNC:16393}
推荐应用
WB
反应种属
Human,Mouse
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Gene ID
84433
Human Swissprot No.
Q9BXL7
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200
预测分子量
133kDa
同种型
Rabbit IgG
注意事项
CARD11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.
细胞定位
Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
功能
Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T- cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108).
期货
现货

Western blot analysis of CARD11 expression in K562 cell lysate.

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