产品名称
ACM2 (5Z12) Rabbit Monoclonal Antibody
别名
CHRM2; HM2; AChR; Acm2;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P08172
免疫原
A synthetic peptide of human Muscarinic Acetylcholine Receptor 2
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:100 IP: 1:20-1:50
注意事项
ACM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}
功能
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
